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Cornell University

Cornell Center for Antimicrobial Resistance Research & Education

Christopher Brown, MD, PhD

Christopher Brown
Christopher Brown received bachelors of science degrees in Chemistry and Human Physiology from the University of Illinois at Urbana Champaign. After a brief stint in industry at Obiter research LLC doing custom chemical synthesis he joined the University of Wisconsin– Madison School of Medicine and Public health medical Scientist Training program. For his thesis research, he worked in the laboratory of Laura L. Kiessling designing chemical glycobiology probes of cell wall biosynthesis enzymes in Mycobacterium tuberculosis. He then completed his medical training at New York Presbyterian Weill-Cornell internal medicine residency and infectious disease fellowship. His research focuses on investigating the transmission biology of Mycobacterium tuberculosis through the lens of regulated gene expression platforms and metabolism.

 

 

Selected Publications

Saito K, Mishra S, Warrier T, Cicchetti N, Mi J, Weber E, Jiang X, Roberts J, Gouzy A, Kaplan E, Brown CD, Gold B, Nathan C. Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected. Science translational medicine 2021, Nov 24;13(621):eabg2612 doi:10.1126/scitranslmed.abg2612

Rendeiro AF, Casano J, Vorkas CK, Singh H, Morales A, DeSimone R, Ellsworth G, Soave R, Kapadia SN, Saito K, Brown CD, Hsu J, Kyriakides C, Chiu S, Cappelli L, Cacciapuoti M, Tam W, Galluzzi L, Simonson PD, Elemento O, Salvatore M, Inghirami G, Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression. Life Science Alliance 2021,4 (2), e202000955.

Brown CD, Rusek MS and Kiessling LL. Fluorosugar chain termination agents as probes of the sequence specificity of the carbohydrate polymerase GlfT2. J. Am. Chem. Soc. 2012, 134(15), 6552 – 6555

May JF, Levengood MR, Splain RA, Brown CD, Kiessling LL. A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site. Biochemistry. 2012, 51(6) 1148 – 1159.

Title: Assistant Professor